An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in Alzheimer's disease, mild cognitive impairment and normal aging.
نویسندگان
چکیده
BACKGROUND This study investigates how T(1)-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. METHODS A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. RESULTS The T(1)- and T(2)-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. CONCLUSION The T(1)-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.
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ورودعنوان ژورنال:
- Dementia and geriatric cognitive disorders
دوره 30 2 شماره
صفحات -
تاریخ انتشار 2010